Astroglial-derived periostin promotes axonal regeneration after spinal cord injury

2020-01-25 06:32

Feb 12, 2014 Traumatic spinal cord injury (SCI) results in a cascade of tissue responses leading to cell death, axonal degeneration, and glial scar formation, exacerbating the already hostile environment and further inhibiting axon regeneration. Overcoming these inhibitory cues and promoting axonal regeneration is one of the primary targets in developing a cure for SCI.We report that inhibiting the generation of progeny by a subclass of pericytes led to decreased fibrosis and extracellular matrix deposition after spinal cord injury in mice. Regeneration of raphespinal and corticospinal tract axons was enhanced and sensorimotor function recovery improved following spinal cord injury in animals with attenuated astroglial-derived periostin promotes axonal regeneration after spinal cord injury

Request PDF on ResearchGate AstroglialDerived Periostin Promotes Axonal Regeneration after Spinal Cord Injury Traumatic spinal cord injury (SCI) results in a cascade of tissue responses

Astroglialderived periostin promotes axonal regeneration after spinal cord injury. Authors: Shih Et al. Auton Neurosci 2014; 34: 2438 OE and tamox. induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low Feb 12, 2014 Astroglialderived periostin promotes axonal regeneration after spinal cord injury. Shih CH(1), Lacagnina M, LeuerBisciotti K, Prschel C. Author information: (1)Stem Cell and Regenerative Medicine Institute, Department of Biomedical Genetics, and Department of Pathology, University of Rochester Medical Center, Rochester, New York.astroglial-derived periostin promotes axonal regeneration after spinal cord injury Periostin Promotes Scar Formation through the Interaction between Pericytes and Infiltrating MonocytesMacrophages after Spinal Cord Injury We further evaluated the axonal regeneration in the injured spinal cord between S. A. Busch, Y. Shen, J. SilverModulation of the proteoglycan receptor PTPsigma promotes recovery after spinal cord

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